Causes of Migraine Attacks

Migraines are considered to be a neurological disorder originating in the brain stem. The brain and the brain stem have nerves that directly arise from them, called cranial nerves. We have 12 pairs of cranial nerves with 10 of those pairs arising directly from the brain stem.

At the junction where cranial nerves connect to the brain stem, there is a collection of neurons called nuclei. Brain stem nuclei directly synapse and connect with one or more cranial nerves to relay their information. There are many nuclei in the brain stem, with the largest nuclei called the trigeminal nucleus.
Scientists believe that over excitation and malfunction of the trigeminal nucleus is the major factor responsible for the origins of migraine. Over excitation of the trigeminal nucleus can be likened to an electrical storm occurring in the brain stem, and this storm being the starting point of a migraine.

The Migraine StopperTM using a technique call neuromodulation to calm down the electrical storm at the trigeminal nucleus to relieve migraine symptoms.

How does the Migraine StopperTM give relief?


The Migraine StopperTM uses neuromodulation, to turn off the symptoms of migraine.

Neuromodulation is the activation of a specific nerve to help alleviate a symptom in a patient.

The Migraine StopperTM supplies gentle and precise positive and negative air pressure in your ear canal. This creates a measured, safe, and gentle push and pull effect on the ear canal and ear drum.

Moving the ear canal and ear drum in this way causes stimulation of two specific cranial nerves, the trigeminal nerve and the vagus nerve.

Research shows that stimulation of the trigeminal nerve and stimulation of the vagus nerve may have a neuromodulation effect of calming down an overactive trigeminal nucleus and stopping the pain of migraine!

Migraine StopperTM is a world first

The Migraine StopperTM is the world’s first patient operated medical device to specifically stimulate the trigeminal verve and the Vagus nerve at the same time, aimed to relieve migraines.

The patented migraine relief valve

To create the appropriate double neuromodulation to relieve the migraine headache a special ‘migraine relief valve’ needed to be created by Dr Adam Meredith.

The challenge was to create an effective air tight seal in the ear canal, while delivering the correct gentle therapeutic positive and negative air pressure to stimulate both the trigeminal and vagus nerve appropriately.

Too much pressure is dangerous for the eardrum and too little does not have a therapeutic effect.

Correct positive and negative air pressure activates the trigeminal nerve and vagus nerve in a controlled way in effect to calm down the overactive the trigeminal nucleus for therapeutic relief of migraine.

The whole process of getting migraines and turning them off is a complicated neurological situation.

In simple terms, the Migraine StopperTM uses a "double action" neuromodulation to the trigeminal and vagus nerves at the same time, for the goal of maximum migraine relief.

Clinical trials indicate that it’s simple, safe, non-invasive and with no drugs or drug side effects.

Trigeminal Nerve and Migraines

(5TH Cranial Nerve)
The trigeminal nerve is the largest of the cranial nerves and is known as the "Great Sensory Nerve of the Head". The trigeminal nerve synapses and connects directly to the brain stem at the trigeminal nucleus. Branches of the trigeminal nerve supply the ear canal and ear drum.

The Migraine StopperTM uses precise air pressure to create specific movements in the ear canal and ear drum. When this is done, studies have reported that the trigeminal nerve registers the movement and relays this “new information” to the trigeminal nucleus. The “new information” has the effect of calming down the overactivity of the trigeminal nucleus.

Vagus Nerve and Migraines

(10th Cranial Nerve)
The vagus nerve is in fact the longest nerve in the body. It travels from your brain stem right down to your abdomen. It innervates many organs including the heart, lung, liver, pancreas and intestines.

It is a major parasympathetic nerve, which controls the “rest and digest” and healing functions of your body. It controls things like, heart rate, digestion, breathing rate and is even involved in helping with chronic inflammation.

The vagus nerve also supplies the ear canal and ear drum and connects to the brain stem at the trigeminal nucleus. When the Migraine StopperTM creates movement in the ear canal and ear drum, this information is relayed by the vagus nerve to the dorsal nucleus of the vagus nerve (in the brain stem) which then interacts with the trigeminal nucleus, having the effect of calming down overactivity.

So the Migraine StopperTMhas a dual action for calming down an overactive trigeminal nucleus by simultaneously stimulating the trigeminal nerve and vagus nerve.

In addition, the parasympathetic system is responsible for calming down the stress centres of the brain stem. When the Migraine StopperTM stimulates the ear canal and drum, parasympathetic information to the brain stem increases via the vagus nerve. Increasing parasympathetic tone has been shown to calm down the brain stem, lower inflammation, relax arterioles and increase blood flow, all which are known to be positive factors in reducing migraines.

The world's first patient operated, double neuromodulation device created to treat migraines!

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